VEGFC anticorps (Biotin)

N° du produit ABIN5540708

Cet anticorps Souris Monoclonal détecte spécifiquement VEGFC dans EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour VEGFC anticorps (Biotin) (ABIN5540708)

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VEGFC est conjugé à/à la Biotin

Application: Enzyme Immunoassay (EIA)

Clone: 107-A11

Détail du produit anti-VEGFC anticorps (Biotin)

Specificité: This antibody recognizes Human VEGF-C. Other species not tested.

Purification: Protein G Chromatography

Immunogène: Recombinant Human VEGF-C (Cat.-No AR01001PU-N)

Isotype: IgG2a

Information d'application

Indications d'application: ELISA: 1-5 μg/mL.

Restrictions: For Research Use only

Stockage

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur VEGFC

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Autre désignation: vegf-c,flt4-l

Sujet: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.

UniProt: P49767

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2